教授

纳米生物学效应、纳米靶向递送、免疫效应性纳米酶。

1.国家自然科学基金面上项目，MoS2纳米酶载药系统靶向调控巨噬细胞线粒体动力重塑动脉粥样斑块微环境的作用机制，2021-2024年，主持

2.国家自然科学基金面上项目，C60衍生物通过调控Nrf2/NF-κB炎症平衡体系抑制小胶质细胞活化的研究2012-2016年，主持

3.国家自然科金青年基金，Nrf2通路在碳纳米管致细胞氧化应激效应中的作用及机制，2009-2012年，主持

4.福建省自然科学基金，新型碳纳米管复合材料用于骨组织缺损修复，2006-2008年，主持

5.教育部留学回国人员启动基金，2004-2007年，主持

1.He Z, Guo Y, Chen J, Luo H, Liu X, Zhang X, Sun Y, Ge D, Ye S, Shi W. Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis. J Mater Chem B. 2023, 11(9):1891-1903.

2.Liu C, Jia S, Tu L, Yang P, Wang Y, Ke S, Shi W, Ye S. GSH-Responsive and Hypoxia-Activated Multifunctional Nanoparticles for Synergetically Enhanced Tumor Therapy. ACS Biomater Sci Eng. 2022, 8(5):1942-1955.

3.Zhao J, Ye Z, Yang J, Zhang Q, Shan W, Wang X, Wang Z, Ye S, Zhou X, Shao Z, Ren L. Nanocage encapsulation improves antiepileptic efficiency of phenytoin. Biomaterials. 2020, 240:119849.

4.Cheng K, Ding Y, Zhao Y, Ye S, Zhao X, Zhang Y, Ji T, Wu H, Wang B, Anderson GJ, Ren L, Nie G. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. Nano Lett. 2018, 18(5):3250-3258.

5.Sunkui Ke, Youlin Lai, Tong Zhou, Lihuang Li, Yange Wang, Lei Ren, and Shefang Ye. Molybdenum Disulfide Nanoparticles Resist Oxidative Stress-Mediated Impairment of Autophagic Flux and Mitigate Endothelial Cell Senescence and Angiogenic Dysfunctions. ACS Biomater. Sci. Eng., 2018, 4 (2): 663–674.

6.Shan W, Zhang D, Wu Y, Lv X, Hu B, Zhou X, Ye S, Bi S, Ren L, Zhang X.Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin. Nanomedicine. 2018, 14(3):725-734.

7.Li Y, Song L, Lin J, Ma J, Pan Z, Zhang Y, Su G, Ye S, Luo FH, Zhu X, Hou Z. Programmed Nanococktail Based on pH-Responsive Function Switch for Self-Synergistic Tumor-Targeting Therapy. ACS Appl Mater Interfaces. 2017, 9(45):39127-39142.

8.Li Y, Lin J, Ma J, Song L, Lin H, Tang B, Chen D, Su G, Ye S, Zhu X, Luo F, Hou Z. Methotrexate-Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy. ACS Appl Mater Interfaces. 2017, 9(40):34650-34665.

9.Cheng Y, Zhang S, Kang N, Huang J, Lv X, Wen K, Ye S, Chen Z, Zhou X, Ren L. Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Appl Mater Interfaces. 2017, 9(22):19296-19306.

10.Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D, Ye S, Chen X, Zhu X, Hou Z. Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy. J Control Release. 2017, 258:95-107.