个人简历

疾病治疗相关：

1. Shan WJ, Wang CF, Chen HX, and Ren L. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

DOI: 10.1021/accountsmr.3c00050

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST, Ren YD, Xu HZ, Luo JG, Wang M, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

DOI: 10.1002/adfm.202304276

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ, Fu G, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

DOI: 10.1002/smll.202301281

4. Guo QY, Wang CF, Zhang Q, Cheng KM, Shan WJ, Wang XM, Yang J, Wang YL, Ren L*. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. APPLIED MATERIALS TODAY 2021; 24: 101110.

DOI: 10.1016/j.apmt.2021.101110

5. Zhang X, Zhang Y, Zheng HP, He YF, Jia HL, Zhang LJ, Lin CJ, Chen S, Zheng JF, Yang QF, Liu T, Pan XC, Zhang HG, Wang CH*, Ren L*, Shan WJ*. In situ biomimetic nanoformulation for metastatic cancer immunotherapy. ACTA BIOMATERIALIA 2021; 134: 633-648.

DOI: 10.1016/j.actbio.2021.07.055

6. Zhang X, Chen Q, Zhang LY, Zheng HP, Lin CJ, Yang QF, Liu T, Zhang HG, Chen XH, Ren L*, Shan WJ*. Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy. JOURNAL OF NANOBIOTECHNOLOGY 2021; 19:156.

DOI: 10.1186/s12951-021-00900-w

7. Shan WJ, Zheng HP, Fu GF, Liu CF, Li ZZ, Ye YH, Zhao J, Xu D, Sun LP, Wang X, Chen XL, Bi SL, Ren L*, Fu G*. Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy. NANO LETTERS 2019, 19: 1719−1727.

DOI: 10.1021/acs.nanolett.8b04722

8. Song CF, Lin TT, Zhang Q, Thayumanavan S*, Ren L*. pH-Sensitive morphological transitions in polymeric tadpole assemblies for programmed tumor therapy. JOURNAL OF CONTROLLED RELEASE 2019, 293: 1-9.

DOI: 10.1016/j.jconrel.2018.10.033

9. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

10. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

11. Chen RH, Huang SS, Lin TT, Ma HS, Shan WJ, Duan F, Lv J, Zhang JD, Ren L, Nie LM*. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes. NATURE NANOTECHNOLOGY 2021; 16: 455-465.

DOI: 10.1038/s41565-020-00844-6

12. Wang JP, Sun JY, Wang YH, Chou TM, Zhang Q, Zhang BL, Ren L*, Wang HJ*. Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. ADVANCED FUNCTIONAL MATERIALS 2020; 30: 1908825.

DOI: 10.1002/adfm.201908825

13. Zhao J, Ye ZS, Yang J, Zhang Q, Shan WJ, Wang XM, Wang ZX, Ye SF, Zhou X, Shao ZC*, Ren L*. Nanocage encapsulation improves antiepileptic efficiency of phenytoin. BIOMATERIALS 2020; 240: 119849.

DOI: 10.1016/j.biomaterials.2020.119849

14. Yang J, Zhang Q, Liu YX, Zhang XJ, Shan WJ, Ye SF, Zhou X, Ge YL, Wang XM*, Ren L*. Nanoparticle-based co-delivery of siRNA and paclitaxel for dual-targeting of glioblastoma. NANOMEDICINE (LONDON, ENGLAND) 2020, 15: 1391-1409.

DOI: 10.2217/nnm-2020-0066.

15. Zhang Q, Xu D, Guo QY, Shan WJ*, Yang J, Lin TT, Ye SF, Zhou Xi, Ge YL, Bi SL, Ren L*. Theranostic Quercetin Nanoparticle for Treatment of Hepatic Fibrosis. BIOCONJUGATE CHEMISTRY 2019, 30: 2939-2946.

DOI: 10.1021/acs.bioconjchem.9b00631

16. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

17. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

18. Shan WJ, Zhang DL, Wu YL, Lv XL, Hu B, Zhou X, Ye SF, Bi SL, Ren L*, Zhang XZ*. Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2018; 14: 725-734.

DOI: 10.1016/j.nano.2017.12.002

19. Shen LH, Zhou J, Wang YX, Kang N, Ke XB, Bi SL, and Ren L*. Efficient encapsulation of Fe₃O₄ nanoparticles into genetically engineered hepatitis B core virus-like particles through a specific interaction for potential bioapplications. SMALL 2015; 11: 1190-1196.

DOI: 10.1002/smll.201401952

生物成像与检测相关：

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L, and Wang M. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

DOI: 10.1002/adma.202312518

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ, Ren L. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

DOI: 10.1021/acsami.3c09690

22. Chen HX, Li BY, Shi SY, Zhou T, Wang XM, Wang ZY, Zhou X, Wang M, Shi W, Ren L*. Au–Fe₃O₄ nanozyme coupled with CRISPR-Cas12a for sensitive and visual antibiotic resistance diagnosing. ANALYTICA CHIMICA ACTA 2023; 1251: 341014.

DOI: 10.1016/j.aca.2023.341014

23. Chen HX, Zhou X, Wang M, Ren L*. Towards Point of Care CRISPR-Based Diagnostics: From Method to Device. JOURNAL OF FUNCTIONAL BIOMATERIALS 2023; 14: 97.

DOI: 10.3390/jfb14020097

24. Li Y, Zhao X, Liu XL, Cheng KM, Han XX, Zhang YL, Min H, Liu GN, Xue JC, Shi J, Qin H, Fan HM*, Ren L*, Nie GJ*. A Bioinspired Nanoprobe with Multilevel Responsive T-1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases. ADVANCED MATERIALS 2020, 32: 1906799.

DOI: 10.1002/adma.201906799

25. Wang JW, Hua GP, Li LH, Li DY, Wang FF, Wu JZ, Ye ZY, Zhou X, Ye SF, Yang J, Zhang XJ, Ren L*. Upconversion nanoparticle and gold nanocage satellite assemblies for sensitive ctDNA detection in serum. ANALYST 2020; 145: 5553-5562.

DOI: 10.1039/d0an00701c

26. Zhou X, Ren L*. Building a Better Magnetic Resonance Imaging Contrast Agent Using Macromolecular Architecture. ACS CENTRAL SCIENCE 2017; 3: 820-822.

DOI: 10.1021/acscentsci.7b00308

27. Liu Y, Kang N, Lv J, Zhou ZJ, Zhao QL, Ma LC, Chen Z, Ren L*, Nie LM*. Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites. ADVANCED MATERIALS 2016; 28: 6411-6419.

DOI: 10.1002/adma.201506460

28. Han Y, Lei SL, Lu JH, He Y, Chen ZW*, Ren L*, Zhou X*. Potential use of SERS-assisted theranostic strategy based on Fe₃O₄/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016; 64: 199-207.

DOI: 10.1016/j.msec.2016.03.090

29. Kang N, Liu Y, Zhou YM, Wang D, Chen C, Ye SF, Nie LM*, Ren L*. Phase and Size Control of Core–Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo. ADVANCED HEALTHCARE MATERIALS 2016, 5,1356-1363

DOI: 10.1002/adhm.201600159

抗菌相关：

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X, and Ren L. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

DOI: 10.1002/adfm.202303147

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M, Ren L. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

DOI: 10.1016/j.cclet.2022.108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ, Ren L. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe₂O₃ for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

DOI: 10.1016/j.chemosphere.2023.138175

33. Zhou YM, Jiang YJ, Cai JF, Wang JP, Li S, Wang M, Zhou X, Zhao XQ*, Ren L*. A core/shell nanogenerator achieving pH-responsive nitric oxide release for treatment of infected diabetic wounds. NANOSCALE 2022, 14: 14984-14996.

DOI: 10.1039/d2nr03704a

34. Zeng S, Wang YH, Zhou YM, Li WL, Zhou WB, Zhou X, Wang M, Zhao XQ*, Ren L*. Mixed-linker synthesis of L-histidine@zeolitic imidazole framework-8 on amyloid nanofibrils-modified polyacrylonitrile membrane with high separation and antifouling properties. SEPARATION AND PURIFICATION TECHNOLOGY 2022; 290: 120856.

DOI: 10.1016/j.seppur.2022.120856

35. Zhou YM, Chen Z, Zeng S, Wang CF, Li WL, Wang M, Wang XM, Zhou X, Zhao XQ*, Ren L*. Optimization of nanostructured copper sulfide to achieve enhanced enzyme-mimic activities for improving anti-infection performance. ACS APPLIED MATERIALS & INTERFACES 2021, 13: 53659-53670.

DOI: 10.1021/acsami.1c17985

36. Zhou YM, Feng H, Jiang YJ, Hua GP, Zhang Q, Zeng S, Li WL, Li LH, Kang N*, Ren L*. Nanoliquid dressing with enhancing anti-infection performance under the moderate photothermal effect for wound treatment. ACS APPLIED MATERIALS & INTERFACES 2021; 13: 18443-18453.

DOI: 10.1021/acsami.0c21854

37. Li WL, Thian ES, Wang M, Wang ZY*, Ren L*. Surface design for antibacterial materials: from fundamentals to advanced strategies. ADVANCED SCIENCE 2021; 8: 2100368.

DOI: 10.1002/advs.202100368

研究领域

（1）基于病毒样颗粒的肿瘤免疫治疗

（2）体外诊断相关的纳米生物技术

（3）新型抗菌、防污材料

（4）仿生微纳米机器人在生物医学中的应用

主要科研成果

已主持多项国家自然科学基金项目，并与多家生物医药企业合作开展转化研究；已获授权中国发明专利20余项。曾荣获2022年度williamhill官方网站主页“田昭武学科交叉奖” （一等奖），2012年度日本陶瓷协会日中陶瓷科学技术交流奖励，2013年厦门市科技进步二等奖。

已授权专利：

1. 任磊，周文博，王苗，李文龙。一种高效促伤口愈合的抗菌水凝胶伤口敷料及其制备方法。专利号：ZL202210452302.7。

2. 聂立铭，陈荣河，任磊。一种具有减脂作用的药用组合物及其应用。专利号：ZL202011181328.X。

3. 任磊，王佳威，李丹阳。一种近红外荧光生物传感器的构建方法和检测方法。专利号：ZL202010059675.9。

4. 任磊，单文俊。重组药物载体蛋白基因及其制备方法与应用。专利号：ZL201710171868.1。

5. 陈志伟，黄建攀，周樨，任磊，程友星。一种碳酸锰纳米复合材料在磁共振成像中的应用。专利号：ZL201710265995.8。

6. 任磊，韩钰，周樨。一种水溶性四氧化三铁纳米粒子的微波合成方法。专利号：ZL201410090607.3。

7. 任磊，周樨，杨安琪。一种表面增强拉曼基底的制备方法。专利号：ZL201410249245.8。

8. 任磊，王东。一种超顺磁性铁氧体纳米粒子的制备方法。专利号：ZL201410089572.1。

9. 任磊，王东。一种上转换荧光/顺磁性双功能纳米晶的制备方法。中国发明专利。专利号：ZL201110303196.8。授权公告号：CN102504820B。授权公告日：2013.9.18。

10. 任磊，王天晓，王军。一种实现肿瘤靶向的非病毒载体的表面修饰方法及其应用。专利号：ZL201110135734.7。

11. 任磊，王军，王林，王俊。一种具有抗感染性的复合组织工程支架材料及其制备方法。专利号：ZL200910112757.9。

12. 任磊，赵阳，王祖勇，张其清。一种用于基因递送的载体的制备方法。专利号：ZL200810071151.0。

13. 任磊，王林，张其清。一种骨/软骨组织工程支架材料及其制备方法。专利号：ZL200810071441.5。

14. 任磊，张其清。一种三维多孔组织工程支架材料及其制备方法。专利号：ZL200410094895.6。

15. 任磊，刘雯，赵雪芹，王军，王俊。一种兼具光敏性和温敏性的纳米水凝胶药物载体材料。专利号：ZL200910112571.3。

16. 张其清，任磊。组织引导再生胶原膜及其制造方法。专利号：ZL94118836.1。

主要代表学术论著与论文

疾病治疗相关：

1. Shan WJ, Wang CF, Chen HX, and Ren L. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

DOI: 10.1021/accountsmr.3c00050

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST, Ren YD, Xu HZ, Luo JG, Wang M, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

DOI: 10.1002/adfm.202304276

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ, Fu G, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

DOI: 10.1002/smll.202301281

4. Guo QY, Wang CF, Zhang Q, Cheng KM, Shan WJ, Wang XM, Yang J, Wang YL, Ren L*. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. APPLIED MATERIALS TODAY 2021; 24: 101110.

DOI: 10.1016/j.apmt.2021.101110

5. Zhang X, Zhang Y, Zheng HP, He YF, Jia HL, Zhang LJ, Lin CJ, Chen S, Zheng JF, Yang QF, Liu T, Pan XC, Zhang HG, Wang CH*, Ren L*, Shan WJ*. In situ biomimetic nanoformulation for metastatic cancer immunotherapy. ACTA BIOMATERIALIA 2021; 134: 633-648.

DOI: 10.1016/j.actbio.2021.07.055

6. Zhang X, Chen Q, Zhang LY, Zheng HP, Lin CJ, Yang QF, Liu T, Zhang HG, Chen XH, Ren L*, Shan WJ*. Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy. JOURNAL OF NANOBIOTECHNOLOGY 2021; 19:156.

DOI: 10.1186/s12951-021-00900-w

7. Shan WJ, Zheng HP, Fu GF, Liu CF, Li ZZ, Ye YH, Zhao J, Xu D, Sun LP, Wang X, Chen XL, Bi SL, Ren L*, Fu G*. Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy. NANO LETTERS 2019, 19: 1719−1727.

DOI: 10.1021/acs.nanolett.8b04722

8. Song CF, Lin TT, Zhang Q, Thayumanavan S*, Ren L*. pH-Sensitive morphological transitions in polymeric tadpole assemblies for programmed tumor therapy. JOURNAL OF CONTROLLED RELEASE 2019, 293: 1-9.

DOI: 10.1016/j.jconrel.2018.10.033

9. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

10. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

11. Chen RH, Huang SS, Lin TT, Ma HS, Shan WJ, Duan F, Lv J, Zhang JD, Ren L, Nie LM*. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes. NATURE NANOTECHNOLOGY 2021; 16: 455-465.

DOI: 10.1038/s41565-020-00844-6

12. Wang JP, Sun JY, Wang YH, Chou TM, Zhang Q, Zhang BL, Ren L*, Wang HJ*. Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. ADVANCED FUNCTIONAL MATERIALS 2020; 30: 1908825.

DOI: 10.1002/adfm.201908825

13. Zhao J, Ye ZS, Yang J, Zhang Q, Shan WJ, Wang XM, Wang ZX, Ye SF, Zhou X, Shao ZC*, Ren L*. Nanocage encapsulation improves antiepileptic efficiency of phenytoin. BIOMATERIALS 2020; 240: 119849.

DOI: 10.1016/j.biomaterials.2020.119849

14. Yang J, Zhang Q, Liu YX, Zhang XJ, Shan WJ, Ye SF, Zhou X, Ge YL, Wang XM*, Ren L*. Nanoparticle-based co-delivery of siRNA and paclitaxel for dual-targeting of glioblastoma. NANOMEDICINE (LONDON, ENGLAND) 2020, 15: 1391-1409.

DOI: 10.2217/nnm-2020-0066.

15. Zhang Q, Xu D, Guo QY, Shan WJ*, Yang J, Lin TT, Ye SF, Zhou Xi, Ge YL, Bi SL, Ren L*. Theranostic Quercetin Nanoparticle for Treatment of Hepatic Fibrosis. BIOCONJUGATE CHEMISTRY 2019, 30: 2939-2946.

DOI: 10.1021/acs.bioconjchem.9b00631

16. Shan WJ, Chen RH, Zhang Q, Zhao J, Chen BB, Zhou X, Ye SF, Bi SL, Nie LM, Ren L*. Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles. ADVANCED MATERIALS 2018, 30: 1707567.

DOI: 10.1002/adma.201707567

17. Cheng KM, Ding YP, Zhao Y, Ye SF, Zhao X, Zhang YL, Ji TJ, Wu HH, Wang B, Anderson GJ, Ren L*, Nie GJ*. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS 2018; 18: 3250-3258.

DOI: 10.1021/acs.nanolett.8b01071

18. Shan WJ, Zhang DL, Wu YL, Lv XL, Hu B, Zhou X, Ye SF, Bi SL, Ren L*, Zhang XZ*. Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2018; 14: 725-734.

DOI: 10.1016/j.nano.2017.12.002

19. Shen LH, Zhou J, Wang YX, Kang N, Ke XB, Bi SL, and Ren L*. Efficient encapsulation of Fe₃O₄ nanoparticles into genetically engineered hepatitis B core virus-like particles through a specific interaction for potential bioapplications. SMALL 2015; 11: 1190-1196.

DOI: 10.1002/smll.201401952

生物成像与检测相关：

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L, and Wang M. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

DOI: 10.1002/adma.202312518

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ, Ren L. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

DOI: 10.1021/acsami.3c09690

22. Chen HX, Li BY, Shi SY, Zhou T, Wang XM, Wang ZY, Zhou X, Wang M, Shi W, Ren L*. Au–Fe₃O₄ nanozyme coupled with CRISPR-Cas12a for sensitive and visual antibiotic resistance diagnosing. ANALYTICA CHIMICA ACTA 2023; 1251: 341014.

DOI: 10.1016/j.aca.2023.341014

23. Chen HX, Zhou X, Wang M, Ren L*. Towards Point of Care CRISPR-Based Diagnostics: From Method to Device. JOURNAL OF FUNCTIONAL BIOMATERIALS 2023; 14: 97.

DOI: 10.3390/jfb14020097

24. Li Y, Zhao X, Liu XL, Cheng KM, Han XX, Zhang YL, Min H, Liu GN, Xue JC, Shi J, Qin H, Fan HM*, Ren L*, Nie GJ*. A Bioinspired Nanoprobe with Multilevel Responsive T-1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases. ADVANCED MATERIALS 2020, 32: 1906799.

DOI: 10.1002/adma.201906799

25. Wang JW, Hua GP, Li LH, Li DY, Wang FF, Wu JZ, Ye ZY, Zhou X, Ye SF, Yang J, Zhang XJ, Ren L*. Upconversion nanoparticle and gold nanocage satellite assemblies for sensitive ctDNA detection in serum. ANALYST 2020; 145: 5553-5562.

DOI: 10.1039/d0an00701c

26. Zhou X, Ren L*. Building a Better Magnetic Resonance Imaging Contrast Agent Using Macromolecular Architecture. ACS CENTRAL SCIENCE 2017; 3: 820-822.

DOI: 10.1021/acscentsci.7b00308

27. Liu Y, Kang N, Lv J, Zhou ZJ, Zhao QL, Ma LC, Chen Z, Ren L*, Nie LM*. Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites. ADVANCED MATERIALS 2016; 28: 6411-6419.

DOI: 10.1002/adma.201506460

28. Han Y, Lei SL, Lu JH, He Y, Chen ZW*, Ren L*, Zhou X*. Potential use of SERS-assisted theranostic strategy based on Fe₃O₄/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016; 64: 199-207.

DOI: 10.1016/j.msec.2016.03.090

29. Kang N, Liu Y, Zhou YM, Wang D, Chen C, Ye SF, Nie LM*, Ren L*. Phase and Size Control of Core–Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo. ADVANCED HEALTHCARE MATERIALS 2016, 5,1356-1363

DOI: 10.1002/adhm.201600159

抗菌相关：

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X, and Ren L. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

DOI: 10.1002/adfm.202303147

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M, Ren L. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

DOI: 10.1016/j.cclet.2022.108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ, Ren L. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe₂O₃ for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

DOI: 10.1016/j.chemosphere.2023.138175

33. Zhou YM, Jiang YJ, Cai JF, Wang JP, Li S, Wang M, Zhou X, Zhao XQ*, Ren L*. A core/shell nanogenerator achieving pH-responsive nitric oxide release for treatment of infected diabetic wounds. NANOSCALE 2022, 14: 14984-14996.

DOI: 10.1039/d2nr03704a

34. Zeng S, Wang YH, Zhou YM, Li WL, Zhou WB, Zhou X, Wang M, Zhao XQ*, Ren L*. Mixed-linker synthesis of L-histidine@zeolitic imidazole framework-8 on amyloid nanofibrils-modified polyacrylonitrile membrane with high separation and antifouling properties. SEPARATION AND PURIFICATION TECHNOLOGY 2022; 290: 120856.

DOI: 10.1016/j.seppur.2022.120856

35. Zhou YM, Chen Z, Zeng S, Wang CF, Li WL, Wang M, Wang XM, Zhou X, Zhao XQ*, Ren L*. Optimization of nanostructured copper sulfide to achieve enhanced enzyme-mimic activities for improving anti-infection performance. ACS APPLIED MATERIALS & INTERFACES 2021, 13: 53659-53670.

DOI: 10.1021/acsami.1c17985

36. Zhou YM, Feng H, Jiang YJ, Hua GP, Zhang Q, Zeng S, Li WL, Li LH, Kang N*, Ren L*. Nanoliquid dressing with enhancing anti-infection performance under the moderate photothermal effect for wound treatment. ACS APPLIED MATERIALS & INTERFACES 2021; 13: 18443-18453.

DOI: 10.1021/acsami.0c21854

37. Li WL, Thian ES, Wang M, Wang ZY*, Ren L*. Surface design for antibacterial materials: from fundamentals to advanced strategies. ADVANCED SCIENCE 2021; 8: 2100368.

DOI: 10.1002/advs.202100368

学位		职称	教授，博士生导师
研究室		所在部门
电子邮件	renlei@xmu.edu.cn	电话
课题组网站

教授

师资队伍

教授

任磊

职称：教授，博士生导师

邮箱：renlei@xmu.edu.cn

个人简历

疾病治疗相关：

1. Shan WJ*, Wang CF, Chen HX, and Ren L*. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST*, Ren YD, Xu HZ, Luo JG, Wang M*, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ*, Fu G*, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

DOI: 10.1002/adfm.201908825

DOI: 10.1016/j.biomaterials.2020.119849

DOI: 10.2217/nnm-2020-0066.

DOI: 10.1021/acs.bioconjchem.9b00631

DOI: 10.1002/smll.201401952

生物成像与检测相关：

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L*, and Wang M*. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ*, Ren L*. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

DOI: 10.3390/jfb14020097

DOI: 10.1002/adma.201906799

DOI: 10.1039/d0an00701c

抗菌相关：

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X*, and Ren L*. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M*, Ren L*. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ*, Ren L*. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe2O3 for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

研究领域

主要科研成果

主要代表学术论著与论文

疾病治疗相关：

1. Shan WJ*, Wang CF, Chen HX, and Ren L*. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST*, Ren YD, Xu HZ, Luo JG, Wang M*, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ*, Fu G*, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

DOI: 10.1002/adfm.201908825

DOI: 10.1016/j.biomaterials.2020.119849

DOI: 10.2217/nnm-2020-0066.

DOI: 10.1021/acs.bioconjchem.9b00631

DOI: 10.1002/smll.201401952

生物成像与检测相关：

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L*, and Wang M*. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ*, Ren L*. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

DOI: 10.3390/jfb14020097

DOI: 10.1002/adma.201906799

DOI: 10.1039/d0an00701c

抗菌相关：

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X*, and Ren L*. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M*, Ren L*. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ*, Ren L*. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe2O3 for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

1. Shan WJ, Wang CF, Chen HX, and Ren L. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST, Ren YD, Xu HZ, Luo JG, Wang M, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ, Fu G, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L, and Wang M. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ, Ren L. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X, and Ren L. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M, Ren L. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ, Ren L. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe₂O₃ for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.

1. Shan WJ, Wang CF, Chen HX, and Ren L. Rational Design of Virus-like Particles for Nanomedicine. ACCOUNT MATERIALS RESEARCH 2023; 4: 814-826.

2. Huang LB, Li LH, Jiang YJ, Cai JF, Cai ST, Ren YD, Xu HZ, Luo JG, Wang M, and Ren L*. Tumbler-Inspired Microneedle Containing Robots: Achieving Rapid Self-Orientation and Peristalsis-Resistant Adhesion for Colonic Administration. ADVANCED FUNCTIONAL MATERIALS 2023; 33: 2304276.

3. Zhang Q, Dong JC, Wang JP, Wang JY, Wang CF, Li Y, Chen XL, Wang XM, Shan WJ, Fu G, Ren L*. Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity. SMALL 2023; 19: 2301281.

20. Li LH, Zhang JL, Jiao ZQ, Zhou X, Ren L, and Wang M. Seamless Integration of Rapid Separation and Ultrasensitive Detection for Complex Biological Samples Using Multistage Annular Functionalized Carbon Nanotube Arrays ADVANCED MATERIALS. 2024: 2312518.

21. Chen HX, Zhou T, Li S, Feng JY, Li WL, Li LH, Zhou X, Wang W, Li F, Zhao XQ, Ren L. Living Magnetotactic Microrobots Based on Bacteria with a Surface Displayed CRISPR/Cas12a System for Penaeus Viruses Detection. ACS APPLIED MATERIALS & INTERFACES 2023; 15: 47930-47938.

30. Li WL, Chen HX, Cai JF, Wang M, Zhou X, and Ren L. Poly(pentahydropyrimidine)-Based Hybrid Hydrogel with Synergistic Antibacterial and Pro-Angiogenic Ability for the Therapy of Diabetic Foot Ulcers. ADVANCED FUNCTIONAL MATERIALS. 2023; 33: 2303147.

31. Wang YH, Jiao ZQ, Li WL, Zeng S, Deng JL, Wang M, Ren L. Superhydrophilic membrane with photo-Fenton self-cleaning property for effective microalgae anti-fouling. CHINESE CHEMICAL LETTERS 2023; 34: 108020

32. Zeng S, Liu YS, Wang YM, Wang YH, Zhou YM, Li LH, Li S, Zhou X, Wang M, Zhao XQ, Ren L. Photo-Fenton self-cleaning carbon fibers membrane supported with Zr-MOF@Fe₂O₃ for effective phosphate removal from algae-rich water. CHEMOSPERE 2023; 323: 138175.